博士，硕士生导师，药物化学方向

主要教育背景及科研经历：
2013年1月—至今 上海交通大学 副教授
2008年3月—2012年12月 上海交通大学 助理研究员
2009年3月—2011年3月 美国德州大学奥斯汀分校 生物工程系 博士后
2007年3月—2008年3月 上海睿智化学有限公司 课题组长
2004年1月—2007年3月 浙江大学yd12300云顶线路 博士
2001年9月—2004年1月 中国矿业大学化工学院 硕士
1997年9月—2001年6月 中国矿业大学化工学院 学士
获得的荣誉：
１、烛光奖二等奖
２、上海交通大学青教赛三等奖
３、扬中市“江雁计划”重点人才项目

主持或参加的主要科研项目
1. 企业合作课题，新型ADC抗肿瘤药物的开发，300万，2021-2024年，主持，在研
2.靶向Kras的抗肿瘤药物的开发，150万，2019年-2022年，主持，在研
3. 国家重点研发计划“蓝色粮仓科技创新”重点专项，2019YFD0901902，基于水产复杂底物的多酶级联及反应分离耦合关键技术，24万， 2020/01-2022/12，子课题，在研
4. 医工合作项目, PS-A多囊脂质体对RDS肺泡巨噬细胞焦亡调控机制的研究， 2017年-2020年，合作主持，在研
5. 国家自然科学基金青年基金，81202397， 以3M-Sortase A 蛋白酶为靶点的抗感染药物的设计，合成及活性研究，23万，2013/01-2015/12，主持，结题
6. 上海市自然科学基金，12ZR1415400，新型苯并呋喃类Sortase A抑制剂的设计、合成及抗感染活性研究，10万，2012/07-2015/06，主持，结题
7.医工合作项目，新型长效胰高血糖素样肽GLP-1类似物的设计、合成及降糖活性研究， 2016年-2018年，合作主持，已结题
8.新型长效胰高血糖素样肽GLP-1类似物的设计、合成及降糖活性研究，yd12300云顶线路，2018年-2019年，主持，已结题

新型药物分子的开发及作用机制研究：
1）新型抗肿瘤药物的研发
2、 新型抗感染药物的研发
3、 新型抗糖尿病药物的研发

1. Wang, Juntao; Lu, Dan; Sun, Ran; Lei, Shuwen; Luo, Shuhua; Dang, Xin; Zhang, Yang; Yuan, Chang; Zhang, Yong; Wu, Jinhong; Yang, Guangyu; Fu, Lei; Jiang, Faqin*. One-​Pot Enzymatic Synthesis and Biological Evaluation of Ganglioside GM3 Derivatives as Potential Cancer Immunotherapeutics, Journal of Medicinal Chemistry (2022), Ahead of Print.
2. Lei, Shuwen; Hu, Yang; Yuan, Chang; Sun, Ran; Wang, Juntao; Zhang, Yong; Zhang, Yang; Lu, Dan; Fu, Lei; Jiang, Faqin*;Discovery of Sortase A covalent inhibitors with benzofuranene cyanide structures as potential antibacterial agents against Staphylococcus aureus, European Journal of Medicinal Chemistry (2022), 229, 114032.
3.Zhang, Dongdong; Hu, Yixin; Hao, Zhiqiang; Zhang, Yang; Luo, Shuhua; Dang, Xin; Sun, Ran; Duan, Shixin; Lv, Dan; Jiang, Faqin; Fu, Lei; Design, synthesis and antitumor activities of thiazole-​containing mitochondrial targeting agents, Bioorganic Chemistry (2021), 115, 105271.
4.Luo, Shuhua; Dang, Xin; Wang, Juntao; Yuan, Chang; Hu, Yixin; Lei, Shuwen; Zhang, Yang; Lu, Dan; Jiang, Faqin; Fu, Lei; Biological evaluation of mitochondria targeting small molecules as potent anticancer drugs, Bioorganic Chemistry (2021), 114, 105055.
5.Dang, Xin; Lei, Shuwen; Luo, Shuhua; Hu, Yixin; Wang, Juntao; Zhang, Dongdong; Lu, Dan; Jiang, Faqin; Fu, Lei; Design, synthesis and biological evaluation of novel thiazole-​derivatives as mitochondrial targeting inhibitors of cancer cells, Bioorganic Chemistry (2021), 114, 105015.
6.Chowdhury, Sharmin Reza; Gu, Jinxin; Hu, Yixin; Wang, Juntao; Lei, Shuwen; Tavallaie, Mojdeh S.; Lam, Celine; Lu, Dan; Jiang, Faqin; Fu, Lei; Synthesis, biological evaluation and molecular modeling of benzofuran piperidine derivatives as Aβ antiaggregant, European Journal of Medicinal Chemistry (2021), 222, 113541.
7.Jian Shen#, Xinxian Deng#, Ran Sun, Mojdeh S. Tavallaie, Juntao Wang, Qingqing Cai, Celine Lam, Shuwen Lei, Lei Fu,* and Faqin Jiang,*. Structural optimization of pyrazolo[1,5-a]pyrimidine derivatives as potent and highly selective DPP-4 inhibitors. European Journal of Medicinal Chemistry, 2020, European Journal of Medicinal Chemistry (2020), 208, 112850.
8.Shuwen Lei, Dongdong Zhang, Yunyue Qi, Sharmin Reza Chowdhury, Ran Sun, Juntao Wang, Hui Zhu, Yi Du, Lei Fu* and Faqin Jiang*, Synthesis and Biological Evaluation of Geniposide derivatives as potent and selective PTPlB inhibitors, European Journal of Medicinal Chemistry, 2020, 205:112508-112520
9. XX Deng, M S. Tavallaiea, R Sun, JT Wang, QQ Cai, J Shen, SW Lei, L Fu⁎, FQ Jiang⁎, Drug discovery approaches targeting the incretin pathway. Bioorganic Chemistry, 2020, 99: 103810.
10. M. Tavallaie, R. Voshtani, X. Deng, Y. Qiao, F. Jiang, J. P. Collman, L. Fu, Moderation of Mitochondrial Respiration Mitigates Metabolic Syndrome of Aging. Proc. Natl. Acad. Sci., (2020), 117(18), 9840-9850.
11. R Sun, XX Deng; DD Zhang; FZ Xie; D Wang; JT Wang; M S Tavallaie, FQ Jiang*, L Fu *, Anti-diabetic potential of Pueraria lobata root extract through promoting insulin signaling by PTP1B inhibition. Bioorganic Chemistry, 2019, 87: 12-15.
12. XX Deng, J Shen, H Zhu, J Xiao, R Sun, FZ Xie, C Lam, JT Wang, YX Qiao, M S Tavallaie, Y Hu, Y Du, JQ Li, L Fu*, FQ Jiang*, Surrogating and redirection of pyrazolo[1,5-a]pyrimidin-7(4H)-one core, a novel class of potent and selective DPP-4 inhibitors. Bioorganic & Medicinal Chemistry, 2018, 2018(26): 903-912.
13. Qiao, Yixue; Dsouza, Charlotte; Matthews, Abigail Ann; Jin, Yan; He, Wan; Bao, Jian; Jiang, Faqin; Chandna, Ritu; Ge, Ruowen; Fu, Lei. Discovery of small molecules targeting GRP78 for antiangiogenic and anticancer therapy, European Journal of Medicinal Chemistry (2020), 193, 112228.
14. Li, Liang; Tavallaie, Mojdeh S.; Xie, Fangzhou; Xia, Yu; Liang, Yaoyao; Jiang, Faqin; Fu, Lei, Identification of lipid-​like salicylic acid-​based derivatives as potent and membrane-​permeable PTP1B inhibitors, Bioorganic Chemistry (2019), 93, 103296.
15. Xie, Fangzhou; Liang, Yaoyao; Xia, Yu; Luo, Shuhua; Jiang, Faqin; Fu, Lei, Discovery of 2-​ethoxy-​4-​(methoxymethyl)​benzamide derivatives as potent and selective PTP1B inhibitors,Bioorganic Chemistry (2019), 92, 103273.
16. Xie, Fangzhou; Yang, Fengzhi; Liang, Yaoyao; Li, Liang; Xia, Yu; Jiang, Faqin; Liu, Wenlu; Qi, Yunyue; Chowdhury, Sharmin Reza; Xie, Dongsheng; et al, Investigation of stereoisomeric bisarylethenesulfonic acid esters for discovering potent and selective PTP1B inhibitors, European Journal of Medicinal Chemistry (2019), 164, 408-422.
17. Burkholder, Nathaniel Tate; Mayfield, Joshua E.; Yu, Xiaohua; Irani, Seema; Arce, Daniel K.; Jiang, Faqin; Matthews, Wendy L.; Xue, Yuanchao; Zhang, Yan Jessie, Journal of Biological Chemistry (2018), 293(43), 16851-16861.
18. Zhang, Wei; Liu, Jingbao; Macho, Jocelyn M.; Jiang, Xizhen; Xie, Dongsheng; Jiang, Faqin; Liu, Wenlu; Fu, Lei, Design, synthesis and antimicrobial evaluation of novel benzoxazole derivatives, Journal of Chemical and Pharmaceutical Research (2016), 8(10), 130-140.
19. Yang, Fengzhi; Xie, Fangzhou; Zhang, Ying; Xia, Yu; Liu, Wenlu; Jiang, Faqin; Lam, Celine; Qiao, Yixue; Xie, Dongsheng; Li, Jianqi; et al, Y-​shaped bis-​arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors, Bioorganic & Medicinal Chemistry Letters (2017), 27(10), 2166-2170.
20. Y Zhang, J Bao, XX Deng, W He, JJ Fan, FQ Jiang*, L Fu, Synthesis, Biological Evaluation and Molecular Docking of 2-Phenyl-Benzo[d]oxazole-7-Carboxamide Derivatives as Potential Staphylococcus aureus Sortase A Inhibitors. Bioorganic & Medicinal Chemistry Letters, 2016,26:4081-4085.
21. W He, J Bao,Y Zhang, XX Deng, JJ Fan, FQ Jiang*, L Fu,Synthesis, Biological Evaluation and Molecular Docking Analysis of 2-phenyl-benzofuran-3-carboxamide derivatives as Potential Inhibitors of Staphylococcus aureus Sortase A, Bioorganic & Medicinal Chemistry, 2016, 25: 1341-1351.
22. Liu, Wenlu; Jiang, Xizhen; Zhang, Wei; Jiang, Faqin; Fu, Lei，Synthesis and antibacterial activity study of C-​3 α,​β-​unsaturated ketone linked benzofuran derivatives， Organic Chemistry: Current Research (2016), 5(1), 164/1-164/7.
23. Zhang, Wei; Liu, Jingbao; Macho, Jocelyn M.; Jiang, Xizhen; Xie, Dongsheng; Jiang, Faqin; Liu, Wenlu; Fu, Lei, Design, synthesis and antimicrobial evaluation of novel benzoxazole derivatives, European Journal of Medicinal Chemistry (2017), 126, 7-14.
24. He, Wan; Xu, Buzhe; Bao, Jian; Deng, Xinxian; Liu, Wenlu; Zhang, Yong; Jiang, Faqin; Fu, Lei, Synthesis and antimicrobial evaluation of 3-​substituted-​imine-​6-​hydroxy-​benzofuran derivatives, Medicinal Chemistry Research (2016), 25(11), 2485-2497.
25. Deng, Xinxian; Liu, Jingbao; Jin, Yan; Zhang, Yong; He, Wan; Bao, Jian; Liu, Wenlu; Jiang, Faqin; Fu, Lei, Identification of 2-​substituted ethenesulfonic acid ester derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatase 1B, Pharmazie (2015), 70(12), 777-783.
26. Jin, Yan; Cheng, Xueheng; Jiang, Faqin; Guo, Zheng; Xie, Jin; Fu, Lei, Application of the ultrafiltration-​based LC-​MS approach for screening PTP1B inhibitors from Chinese red yeast rice, Analytical Methods (2016), 8(2), 353-361.
27. Liu, Jingbao; Deng, Xinxian; Jin, Yan; Xu, Buzhe; Liu, Wenlu; Jiang, Faqin; Fu, Lei, Design, synthesis, and biological evaluation of 2-​substituted ethenesulfonic acid ester derivatives as selective PTP1B inhibitors, Pharmazie (2015), 70(7), 446-451.
28. Xiang, Liang; Moncivais, Kathryn; Jiang, Faqin; Willams, Blake; Alfonta, Lital; Zhang, Zhiwen J., Crucial optimization of translational components towards efficient incorporation of unnatural amino acids into proteins in mammalian cells, PLoS One (2013), 8(7), e67333.
29. Zhu, Jie; Xiang, Liang; Jiang, Faqin; Zhang, Zhiwen J.Equilibrium of sortase A dimerization on Staphylococcus aureus cell surface mediates its cell wall sorting activity,Experimental Biology and Medicine (London, United Kingdom) (2016), 241(1), 90-100.
30. JB Liu, FQ Jiang*, Y Jin, JJ Liu, WL Liu, and L Fu, Design, synthesis, and evaluation of 2-substituent ethenesulfonic acid ester derivatives as novel protein tyrosine phosphatase 1B inhibitors, European Journal of Medicinal Chemistry, 2012, 57, 10-20.
31. JB Liu1, FQ Jiang1, XZ Jiang, W Zhang, JJ Liu, WL Liu, L Fu, Synthesis and antimicrobial evaluation of 3-methanone-6-substituent-benzofuran derivatives, European Journal of Medicinal Chemistry, 2012, 54 , 879-886
32. Zhang, Wei; Liu, Wenlu; Jiang, Xizhen; Jiang, Faqin; Fu, Lei, One-​pot synthesis of hydroxybenzo[d]​oxazole-​2-​aliphatic acid derivatives by Meerwein's reagent, Synthetic Communications (2012), 42(18), 2772-2779.
33. XZ Jiang, WL Liu, W Zhang, FQ Jiang, L Fu, Synthesis and antimicrobial evaluation of new benzofuran derivatives, European Journal of Medicinal Chemistry, 2011, 46, 3526-3530.
34. Aiko Umeda, GN Thibodeaux, K Moncivais, FQ Jiang and Z J Zhang. A versatile approach to transform low-affinity peptides into protein probes with cotranslationally expressed chemical cross-linker. Anal Biochem. 2010,405(1), 82-88.

授权专利：
1.傅磊，姜发琴，徐步哲，包健，何宛，张勇；苯并呋喃类化合物及其制备、用途，专利号：CN201410753236.2
2.傅磊，姜发琴，包健，张勇,何宛，邓新贤；苯并恶唑类化合物及其制备方法和用途；专利号：205101319983
3. 傅磊，姜发琴，何宛，张勇，邓新贤，郭秋圆； 苯并呋喃类化合物及其制备方法和应用，专利号：CN201510657959.7
4.傅磊，谢方洲，杨凤志，谢东升，姜发琴，亓云月，李亮 ，张赢，郭秋圆，孙冉，俞骥昊 ，一种新型PTP1B酶抑制剂及其制备方法和应用，CN201710160612.0
5.傅磊，邓欣贤，姜发琴，肖佳，沈坚，朱惠，一种DPP-4酶抑制剂及其制备和应用，专利号：CN201710440040.1
6.傅磊，张赢，杨凤志，谢方洲，邓欣贤，乔祎雪，姜发琴，谢东升；一种新型乙酰胆碱酯酶抑制剂及其制备方法和应用，专利号：CN201710818243.X