Our research interests are in the development of biodegradable polymers for biomedical and pharmaceutical applications; nano-/micro- particles for drug delivery; combined drug and medical device; and implantable drug delivery system. Over the past 10 years, We focused on the development of: 1) novel biodegradable and biocompatible polymer drug carriers; 2) novel drug delivery systems (DDSs) and nanotechnology, including micro-/nano- scale DDS and stent based DDS.
Publications & Patents
Tan, H, Guo, S, Yang, S, Xu, X,Tang, T, Physical characterization and osteogenic activity of the quaternized chitosan-loaded PMMA bone cement. Acta Biomaterialia, 2012. In press.
Tan, H, Peng, Z, Li, Q, Xu, X, Guo, S,Tang, T, The use of quaternised chitosan-loaded PMMA to inhibit biofilm formation and downregulate the virulence-associated gene expression of antibiotic-resistant staphylococcus. Biomaterials, 2012. 33(2): p. 365-377.
Liu, L, Wang, Y, Guo, S, Wang, Z,Wang, W, Porous polycaprolactone/nanohydroxyapatite tissue engineering scaffolds fabricated by combining NaCl and PEG as co-porogens: Structure, property, and chondrocyte-scaffold interaction in vitro. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2012. In press.
Rong, HJ, Chen, WL, Guo, SR, Lei, L,Shen, YY, PCL films incorporated with paclitaxel/5-fluorouracil: Effects of formulation and spacial architecture on drug release. International Journal of Pharmaceutics, 2012. 427(2): p. 242-51.
Hou, JW, Qian, CY, Zhang, YT,Guo, SR, Application of poly(ethylene glycol)-b-poly(ε-caprolactone) copolymers with different poly(ethylene glycol) contents for the preparation of PEG-coated nanoparticles. Journal of Biomedical Nanotechnology, 2012. In press.
Chen, W, Shen, Y, Rong, H, Lei, L,Guo, S, Development and application of a validated gradient elution HPLC method for simultaneous determination of 5-fluorouracil and paclitaxel in dissolution samples of 5-fluorouracil/paclitaxel-co-eluting stents. Journal of Pharmaceutical and Biomedical Analysis, 2012. 59: p. 179-83.8
Chen, S, Guo, D, Guo, B, Liu, J, Shen, Y, Xu, X, Huang, W,Guo, S, Investigation on formulation and preparation of adenovirus encoding human endostatin lyophilized powders. International Journal of Pharmaceutics, 2012. 427(2): p. 145-152.
